tailieunhanh - Absorption of Toxicants

Describe the ways in which toxicants interact with cells. • Recognize how the molecular characteristics of toxicants affect entrance into a cell. • Explain human anatomy as related to integumentary, respiratory and digestive systems. • Summarize the routes of toxicant absorption. | Absorption of Toxicants Principles of Environmental Toxicology Instructor Gregory Möller . University of Idaho Principles of Environmental Toxicology Learning Objectives Describe the ways in which toxicants interact with cells. Recognize how the molecular characteristics of toxicants affect entrance into a cell. Explain human anatomy as related to integumentary respiratory and digestive systems. Summarize the routes of toxicant absorption. 2 Principles of Environmental Toxicology Organization of the Body 3 Principles of Environmental Toxicology Metabolism Molecular Organization Biosynthesis Catabolism Enzymes ATP MONOMERS POLYMER L 7 subunits macromolecules Adenylic acid saccaharides polysaccharides glucose glycogen amino acids proteins nucleotides DNA RNA 4 Noguchi Principles of Environmental Toxicology Principles of Environmental Toxicology Composition of Bacteria Cell Structure E. coli of total weight Types of molecules Water 70 1 Proteins 15 3000 Nucleic Acids DNA 1 1 RNA 6 3000 Polysaccharides 3 5 Lipids 2 20 Building block 2 500 molecules Inorganic ions 5 1 20 Basic Cell Structure Gal apparatus Cytoplasm membrane Rough iimiuplnsniu 1 replication transcription translation Principles of Environmental Toxicology The Cell ribosomes Principles of Environmental Toxicology Proteins Synthesized primarily during a process called translation. Building blocks of proteins are amino acids. Proteins are made of a long chain of amino acids - Peptide bonds disulfide bonds Cys . - Primary structure is sequence. Sometimes modified by - Heme sugars phosphates. cytoplasm 7 8 Principles of Environmental Toxicology Amino Acids O O O H2N CH-C OH H2N CH-C OH h2N CH-C OH 2 CH3 CH2 ch2 Ala C O SH OH Asp Cys Principles of Environmental Toxicology Amino Acid Chains Phe 9 Principles of Environmental Toxicology Protein Space Filling Model Principles of Environmental Toxicology a Helix Secondary Structure 2 Principles of Environmental Toxicology Protein Functions Antibodies. - .