tailieunhanh - Báo cáo y học: "Boundary effects influence velocity of transverse propagation of simulated cardiac action potentials"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Boundary effects influence velocity of transverse propagation of simulated cardiac action potentials | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Boundary effects influence velocity of transverse propagation of simulated cardiac action potentials Nicholas Sperelakis 1 Bijoy Kalloor2 and Lakshminarayanan Ramasamy2 Address 1Dept. of Molecular Cellular Physiology University of Cincinnati College of Medicine Cincinnati OH 45267-0576 USA and 2Dept. of Electrical Computer Engineering and Computer Science University of Cincinnati College of Engineering Cincinnati OH 45221 USA Email Nicholas Sperelakis - spereln@ Bijoy Kalloor - kalloobs@ Lakshminarayanan Ramasamy- lramasamy@ Corresponding author Published 06 September 2005 Received 18 July 2005 Theoretical Biology and Medical Modelling 2005 2 36 doi 1742-4682-2-36 Accepted 06 September 2005 This article is available from http content 2 1 36 2005 Sperelakis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We previously demonstrated that transverse propagation of excitation cardiac action potentials simulated with PSpice could occur in the absence of low-resistance connections gap - junction channels between parallel chains of myocardial cells. The transverse transmission of excitation between the chains was strongly dependent on the longitudinal resistance of the interstitial fluid space between the chains the higher this resistance the closer the packing of the parallel chains within the bundle. The earlier experiments were carried out with 2-dimensional sheets of cells 2 X 3 3 X 4 and 5 X 5 models where the first number is the number of parallel chains and the second is the number of cells in each chain . The purpose of the present study was to enlarge the model .