tailieunhanh - Báo cáo y học: "Nucleic acid chaperons: a theory of an RNA-assisted protein folding"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Nucleic acid chaperons: a theory of an RNA-assisted protein folding | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Nucleic acid chaperons a theory of an RNA-assisted protein folding Jan C Biro Address Homulus Foundation 88 Howard 1205 San Francisco 94 105 CA USA Email Jan C Biro - Corresponding author Published 01 September 2005 Received 10 July 2005 Theoretical Biology and Medical Modelling 2005 2 35 doi 1742-4682-2-AcCepted 01 September 2005 35 This article is available from http content 2 1 35 2005 Biro licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Summary Background Proteins are assumed to contain all the information necessary for unambiguous folding Anfinsen s principle . However ab initio structure prediction is often not successful because the amino acid sequence itself is not sufficient to guide between endless folding possibilities. It seems to be a logical to try to find the missing information in nucleic acids in the redundant codon base. Results mRNA energy dot plots and protein residue contact maps were found to be rather similar. The structure of mRNA is also conserved if the protein structure is conserved even if the sequence similarity is low. These observations led me to suppose that some similarity might exist between nucleic acid and protein folding. I found that amino acid pairs which are co-located in the protein structure are preferentially coded by complementary codons. This codon complementarity is not perfect it is suboptimal where the 1st and 3rd codon residues are complementary to each other in reverse orientation while the 2nd codon letters may be but are not necessarily complementary. Conclusion Partial complementary coding of co-locating amino acids in protein structures suggests .