tailieunhanh - Báo cáo y học: "On the number of founding germ cells in humans"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: On the number of founding germ cells in humans | Theoretical Biology and Medical Modelling Research On the number of founding germ cells in humans Chang-Jiang Zheng 1 E Georg Luebeck2 Breck Byers3 and Suresh H Moolgavkar2 BioMed Central Open Access Address Department of Occupational and Environmental Medicine Regions Hospital University of Minnesota 640 Jackson Street Saint Paul MN 55101 USA 2Division of Public Health Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North Seattle WA 98109 USA and 3Department of Genome Sciences University of Washington Seattle WA 98195 USA Email Chang-Jiang Zheng - zhen0075@ E Georg Luebeck - gluebeck@ Breck Byers - byers@ Suresh H Moolgavkar - smoolgav@ Corresponding author Published 24 August 2005 Received 01 June 2005 Theoretical Biology and Medical Modelling 2005 2 32 doi 1742-4682-2-32 Accepted 24 August 2005 This article is available from http content 2 1 32 2005 Zheng et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The number of founding germ cells FGCs in mammals is of fundamental significance to the fidelity of gene transmission between generations but estimates from various methods vary widely. In this paper we obtain a new estimate for the value in humans by using a mathematical model of germ cell development that depends on available oocyte counts for adult women. Results The germline-development model derives from the assumption that oogonial proliferation in the embryonic stage starts with a founding cells at t 0 and that the subsequent proliferation can be defined as a simple stochastic birth process. It follows that the population size X t at the end of germline expansion around the 5th month of pregnancy in .