tailieunhanh - Báo cáo y học: "Vasculature deprivation – induced osteonecrosis of the rat femoral head as a model for therapeutic trials"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Vasculature deprivation – induced osteonecrosis of the rat femoral head as a model for therapeutic trials | BioMed Central Theoretical Biology and Medical Modelling Review Open Access Vasculature deprivation - induced osteonecrosis of the rat femoral head as a model for therapeutic trials Jacob Bejar1 Eli Peled2 and Jochanan H Boss 1 Address Department of Pathology The Bnai-Zion Medical Center and The Bruce Rapapport Faculty of Medicine Technion-Israel Institute of Technology Haifa Israel and 2Department of Orthopaedic Surgery B Rambam Medical Center and the Bruce Rappaport Faculty of Medicine Technion-Israel Institute of Technology Haifa Israel Email Jacob Bejar - Eli Peled - peledeli@ Jochanan H Boss - jhboss@ Corresponding author Published 05 July 2005 Received 13 February 2005 Theoretical Biology and Medical Modelling 2005 2 24 doi 1742-4682-2-AcCepted 05 July 2005 24 This article is available from http content 2 1 24 2005 Bejar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Experimental Osteonecrosis The authors experience with experimentally produced femoral capital osteonecrosis in rats is reviewed incising the periosteum at the base of the neck of the femur and cutting the ligamentum teres leads to coagulation necrosis of the epiphysis. The necrotic debris is substituted by fibrous tissue concomitantly with resorption of the dead soft and hard tissues by macrophages and osteoclasts respectively. Progressively the formerly necrotic epiphysis is repopulated by hematopoietic-fatty tissue and replaced by architecturally abnormal and biomechanically weak bone. The femoral heads lose their smooth-surfaced hemispherical shape in the wake of the load transfer through the hip joint such that together with regressive changes of the joint .