tailieunhanh - Báo cáo y học: "An ETP model (exclusion-tolerance-progression) for multi drug resistance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: An ETP model (exclusion-tolerance-progression) for multi drug resistance | Theoretical Biology and Medical Modelling BioMed Central Research Open Access An ETP model exclusion-tolerance-progression for multi drug resistance Subburaj Kannan Address Division of Gastroenterology School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Email SubburajKannan - sukannan@ Corresponding author Published 27 April 2005 Received 22 December 2004 Theoretical Biology and Medical Modelling 2005 2 17 doi 1742-4682-2-17 Accepted 27 April 2005 This article is available from http content 2 1 17 2005 Kannan licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It is known that sensitivity or resistance of tumor cells to a given chemotherapeutic agent is an acquired characteristic s depending on the heterogeneity of the tumor mass subjected to the treatment. The clinical success of a chemotherapeutic regimen depends on the ratio of sensitive to resistant cell populations. Results Based on findings from clinical and experimental studies a unifying model is proposed to delineate the potential mechanism by which tumor cells progress towards multi drug resistance resulting in failure of chemotherapy. Conclusion It is suggested that the evolution of multi drug resistance is a developmentally orchestrated event. Identifying stage-specific time windows during this process would help to identify valid therapeutic targets for the effective elimination of malignancy. Background The phenomenon of drug resistance is a distinct and multifactorial entity culminating in the failure of therapeutic regimens in clinical oncology. From the clinical perspective the emergence of drug resistance is determined by the rate of tumor growth in conjunction with the remission index .

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