tailieunhanh - Báo cáo y học: "Breakdown of accommodation in nerve: a possible role for persistent sodium current"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Breakdown of accommodation in nerve: a possible role for persistent sodium current | Theoretical Biology and Medical Modelling BioMed Central Research Breakdown of accommodation in nerve a possible role for persistent sodium current Kristian Hennings Lars Arendt-Nielsen and Ole K Andersen Open Access Address Center for Sensory-Motor Interaction SMI Aalborg University. Frederik Bajers Vej D3-203 9220 Aalborg 0 Denmark Email Kristian Hennings - krist@ Lars Arendt-Nielsen - lan@ Ole K Andersen - oka@ Corresponding author Published 12 April 2005 Received 08 December 2004 Theoretical Biology and Medical Modelling 2005 2 16 doi 1742-4682-2-16 Accepted 12 April 2005 This article is available from http content 2 1 16 2005 Hennings et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Accommodation and breakdown of accommodation are important elements of information processing in nerve fibers as they determine how nerve fibers react to natural slowly changing stimuli or electrical stimulation. The aim of the present study was to elucidate the biophysical mechanism of breakdown of accommodation which at present is unknown. Results A model of a space-clamped motor nerve fiber was developed. It was found that this new model could reproduce breakdown of accommodation when it included a low-threshold rapidly activating persistent sodium current. However the phenomenon was not reproduced when the persistent sodium current did not have fast activation kinetics or a low activation threshold. Conclusion The present modeling study suggests that persistent low-threshold rapidly activating sodium currents have a key role in breakdown of accommodation and that breakdown of accommodation can be used as a tool for studying persistent sodium current under .