tailieunhanh - Báo cáo y học: "The quantitation of buffering action II. Applications of the formal & general approach"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The quantitation of buffering action II. Applications of the formal & general approach | Theoretical Biology and Medical Modelling BioMed Central Research Open Access The quantitation of buffering action II. Applications of the formal general approach Bernhard M Schmitt Address Department of Anatomy University of Wurzburg 97070 Wurzburg Germany Email Bernhard M Schmitt - Corresponding author Published 16 March 2005 Received 26 August 2004 Theoretical Biology and Medical Modelling 2005 2 9 doi 1742-4682-2-9 Accepted 16 March 2005 This article is available from http content 2 1 9 2005 Schmitt licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The paradigm of buffering originated in acid-base physiology but was subsequently extended to other fields and is now used for a wide and diverse set of phenomena. In the preceding article we have presented a formal and general approach to the quantitation of buffering action. Here we use that buffering concept for a systematic treatment of selected classical and other buffering phenomena. Results H buffering by weak acids and self-buffering in pure water represent conservative buffered systems whose analysis reveals buffering properties that contrast in important aspects from classical textbook descriptions. The buffering of organ perfusion in the face of variable perfusion pressure also termed autoregulation can be treated in terms of non-conservative buffered systems the general form of the concept. For the analysis of cytoplasmic Ca concentration transients also termed muffling we develop a related unit that is able to faithfully reflect the time-dependent quantitative aspect of buffering during the pre-steady state period. Steady-state buffering is shown to represent the limiting case of .

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