tailieunhanh - Báo cáo y học: " Acute renal failure in an AIDS patient on tenofovir: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Acute renal failure in an AIDS patient on tenofovir: a case report | Journal of Medical Case Reports BioMed Central Case report Open Access Acute renal failure in an AIDS patient on tenofovir a case report Pinelopi P Kapitsinou1 and Naheed Ansari 2 Address Department of Medicine Jacobi Medical Center Albert Einstein College of Medicine Bronx New York USA and 2Division of Nephrology Department of Medicine Jacobi Medical Center Albert Einstein College of Medicine Bronx New York USA Email Pinelopi P Kapitsinou - kapitsinou@ Naheed Ansari - Corresponding author Published 31 March 2008 Received II June 2007 Journal of Medical Case Reports 2008 2 94 doi 1752-1947-2-94 Accepted 31 March 2008 This article is available from http content 2 1 94 2008 Kapitsinou and Ansari licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Tenofovir is a potent nucleotide analogue reverse-transcriptase inhibitor used with other antiretroviral agents for the treatment of human immunodeficiency virus HIV infection. Despite the absence of renal toxicity observed in the major clinical trials of tenofovir several case reports of acute renal failure ARF and proximal tubule dysfunction have been described. Case presentation We report a patient who developed ARF and Fanconi syndrome during treatment with tenofovir. Despite severe metabolic acidosis associated with a creatinine of mg dL 866 pmol L this patient s condition improved on discontinuation of tenofovir treatment without requiring renal replacement therapy. Conclusion Vigilant screening of kidney function is required regularly after initiation of tenofovir due to possible appearance of renal failure. Introduction Tenofovir is a nucleotide reverse-transcriptase inhibitor which was