tailieunhanh - Báo cáo y học: " Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults. | Adamzik et al. Critical Care 2010 14 R178 http content 14 5 R178 c CRITICAL CARE RESEARCH Open Access Comparison of thromboelastometry with procalcitonin interleukin 6 and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults 1 111 2 3 Michael Adamzik Martin Eggmann Ulrich H Frey Klaus Gorlinger Martina Brocker-PreuB Gunter Marggraf Cl I -X c -X XX XX X4 I I zx I S zx r Czx zx zx xzx l-x -5 11 I m Dzxt xzr 1 K l-x . .l Xi-x - I I X r zzx -X XX XX 1 Fuat saner Holger Eggeorecht Jurgen Peters Matthias Hartmann Abstract Introduction Established biomarkers for the diagnosis of sepsis are procalcitonin interleukin 6 and C-reactive protein. Although sepsis evokes changes of coagulation and fibrinolysis it is unknown whether thromboelastometry can detect these alterations. We investigated whether thromboelastometry variables are suitable as biomarkers for severe sepsis in critically ill adults. Methods In the observational cohort study blood samples were obtained from patients on the day of diagnosis of severe sepsis n 56 and from postoperative patients n 52 and clotting time clot formation time maximum clot firmness alpha angle and lysis index were measured with thromboelastometry. In addition procalcitonin interleukin 6 and C-reactive protein levels were determined. For comparison of biomarkers receiver operating characteristic ROC curves were used and the optimal cut-offs and odds ratios were calculated. Results In comparison with postoperative controls patients with sepsis showed an increase in lysis index 97 versus 92 P mean and SEM and procalcitonin ng ml versus P . Clotformation time alpha angle maximum clot firmness as well as interleukin 6 and C-reactive protein concentrations were not different between groups clotting time was slightly prolonged. ROC analysis demonstrated an area under the curve AUC of CI - for the lysis index and CI - for .