tailieunhanh - Báo cáo y học: "Too cold may not be so cool: spontaneous hypothermia as a marker of poor "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Too cold may not be so cool: spontaneous hypothermia as a marker of poor outcome after cardiac arrest. | Worner and Oddo Critical Care 2010 14 1002 http content 14 5 1002 CRITICAL CARE COMMENTARY L__ Too cold may not be so cool spontaneous hypothermia as a marker of poor outcome after cardiac arrest Jakobea Worner and Mauro Oddo See related research by den Hartog etal. http content 14 3 R121 Abstract In a recent issue of Critical Care den Hartog and colleagues show an association between spontaneous hypothermia defi ned by an admission body temperature 35 C and poor outcome in patients with coma after cardiac arrest CA treated with therapeutic hypothermia TH . Given that TH alters neurological prognostication studies aiming to identify early markers of injury severity and outcome are welcome since they may contribute overall to optimize the management of comatose CA patients. This study provides an important message to clinicians involved in post-resuscitation care and raises important questions that need to be taken into account in future studies. den Hartog and colleagues prospectively analyzed data from 105 consecutive comatose patients resuscitated from cardiac arrest CA and treated with therapeutic hypothermia TH over a 2-year period 1 . They observed that the percentage of patients with unfavourable outcome including death vegetative state and severe disability was significantly higher in patients with spontaneous hypothermia 69 than in those with a body temperature 35 C on admission to the ICU 50 P . Using multivariable analysis and adjusting for age initial arrest rhythm and APACHE II and SOFA scores the association between spontaneous hypothermia and outcome at 6 months was confirmed. In this single centre prospective cohort of more than 100 patients spontaneous hypothermia remained Correspondence Department of Intensive Care Medicine Lausanne University Hospital Centre Hospitalier Universitaire Vaudois Rue du Bugnon 46 1011 Lausanne Switzerland 2 BioMed Central 2010 BioMed Central Ltd signific antly .

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