tailieunhanh - Báo cáo y học: "GAS6 in systemic inflammatory diseases: with and without infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: GAS6 in systemic inflammatory diseases: with and without infection. | Hurtado and García de Frutos Critical Care 2010 14 1003 http content 14 5 1003 CRITICAL CARE COMMENTARY L__ GAS6 in systemic inflammatory diseases with and without infection Begona Hurtado and Pablo García de Frutos See related research by Ekman etal. http content 14 4 R158 Abstract Vitamin K-dependent proteins are not only essential regulators of blood coagulation. A recent paper in Critical Care describes the levels of the vitamin K-dependent GAS6 and the soluble form of its receptor Axl in plasma from patients with sepsis of systemic inflammation. The results confirm that GAS6 is elevated during septicemia but the fact that inflammatory conditions without infection produce a similar effect suggests it is inflammation that induces the synthesis of GAS6 rather than the interactions with bacteria or other infectious agents. The soluble form of the GAS6 receptor Axl was induced less compared with the effect observed in GAS6. This is important as the two proteins form an inactive complex in plasma suggesting that a functional GAS6 form could be synthesized under these conditions. GAS6 has been proposed as a broad regulator of the innate immune response. GAS6 synthesis is therefore likely to be a regulatory mechanism during systemic inflammation. Recent advances provide the necessary tools for further research including genetic screenings of the components of this system. Since its discovery in 1929 as the Koagulations-Vitamin by Henrik Dam the main role assigned to vitamin K has been linked to maintaining hemostasis. Vitamin K inhibitors have been used in the clinic as anticoagulants since the 1950s. Vitamin K is an essential cofactor in the post-transcriptional modification of glutamic residues of a small number of proteins in the human genome. Although the majority of these vitamin K-dependent proteins are part of the coagulation cascade or its regulators others are involved in different processes. The Correspondence .

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