tailieunhanh - Báo cáo y học: "Interferon-b attenuates lung inflammation following experimental subarachnoid hemorrhage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Interferon-b attenuates lung inflammation following experimental subarachnoid hemorrhage. | Cobelens et al. Critical Care 2010 14 R157 http content 14 4 R157 c CRITICAL CARE RESEARCH Open Access Interferon-p attenuates lung inflammation following experimental subarachnoid hemorrhage Picutor f. l .j c - 2 . ri Ar A Tiohtcvcdì3 Rich M Pliilzhi iver 3 -Wcr U W dor K lcuirlo4 Ronó YvA zirtHr d3 Pieter M LUcIcns Ivo ACW llcusi Ric M Pliuizell reter H vail el Mele ive Zwart o Cobi J Heijnen2 Jozef Kesecioglu1 Walter M van den Bergh1 5 Abstract Introduction Aneurysmal subarachnoid hemorrhage SAH affects relatively young people and carries a poor prognosis with a case fatality rate of 35 . One of the major systemic complications associated with SAH is acute lung injury ALI which occurs in up to one-third of the patients and is associated with poor outcome. ALI in SAH may be predisposed by neurogenic pulmonary edema NPE and inflammatory mediators. The objective of this study was to assess the immunomodulatory effects of interferon-p IFN-P on inflammatory mediators in the lung after experimental SAH. Methods Male Wistar rats were subjected to the induction of SAH by means of the endovascular filament method. Sham-animals underwent sham-surgery. Rats received IFN-p for four consecutive days starting at two hours after SAH induction. After seven days lungs were analyzed for the expression of inflammatory markers. Results SAH induced the influx of neutrophils into the lung and enhanced expression of the pulmonary adhesion molecules E-selectin inter-cellular adhesion molecule ICAM -1 and vascular cell adhesion molecule VCAM -1 compared to sham-animals. In addition SAH increased the expression of the chemokines macrophage inflammatory protein MIP -la MIP-2 and cytokine-induced neutrophil chemoattractant CINC -1 in the lung. Finally tumor necrosis factor-a TNF-a was significantly increased in lungs from SAH-animals compared to shamanimals. IFN-p effectively abolished the SAH-induced expression of all pro-inflammatory mediators in the lung. Conclusions .