tailieunhanh - Báo cáo y học: " Effect of oral beta-blocker on short and longterm mortality in patients with acute respiratory failure: results from the BASEL II-ICU study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of oral beta-blocker on short and longterm mortality in patients with acute respiratory failure: results from the BASEL II-ICU study. | Noveanu et al. Critical Care 2010 14 R198 http content 14 6 R198 c CRITICAL CARE RESEARCH Open Access Effect of oral beta-blocker on short and longterm mortality in patients with acute respiratory failure results from the BASEL II-ICU study 1 12 3 2 4 Markus Noveanu Tobias Breidthardt Tobias Reichlin Etienne Gayat Mihael Potocki Hans Pargger 5 1 1 1 3 1 Antje Heise Julia Meissner Raphael Twerenbold Natalia Muravitskaya Alexandre Mebazaa Christian Mueller Abstract Introduction Acute respiratory failure ARF is responsible for about one-third of intensive care unit ICU admissions and is associated with adverse outcomes. Predictors of short- and long-term outcomes in unselected ICU-patients with ARF are ill-defined. The purpose of this analysis was to determine predictors of in-hospital and one-year mortality and assess the effects of oral beta-blockers in unselected ICU patients with ARF included in the BASEL-II-ICU study. Methods The BASEL II-ICU study was a prospective multicenter randomized single-blinded controlled trial of 314 mean age 70 62 to 79 years ICU patients with ARF evaluating impact of a B-type natriuretic peptide- BNP guided management strategy on short-term outcomes. Results In-hospital mortality was 16 51 patients and one-year mortality 41 128 patients . Multivariate analysis assessed that oral beta-blockers at admission were associated with a lower risk of both in-hospital HR to P and one-year mortality HR to P . Kaplan-Meier analysis confirmed the lower mortality in ARF patients when admitted with oral beta-blocker and further shows that the beneficial effect of oral beta-blockers at admission holds true in the two subgroups of patients with ARF related to cardiac or noncardiac causes. Kaplan-Meier analysis also shows that administration of oral beta-blockers before hospital discharge gives striking additional beneficial effects on one-year mortality. Conclusions Established beta-blocker .