tailieunhanh - Báo cáo y học: "Bench-to-bedside review: Targeting antioxidants to mitochondria in seps"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis. | Galley Critical Care 2010 14 230 http content 14 4 230 CRITICAL CARE REVIEW L_ Bench-to-bedside review Targeting antioxidants to mitochondria in sepsis Helen F Galley Abstract Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances complex interacting antioxidant defense systems control oxidative stress within mitochondria. However no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress including sepsis in which antioxidants targeted at mitochondria have shown promise and the future implications for such approaches in patients. Sepsis is a major cause of mortality in intensive care units. Sepsis is a leading cause of death in both developed and underdeveloped countries and the incidence is increasing each year worldwide sepsis affects about 18 million people every year 1 . Sepsis has a mortality rate of around 25 for uncomplicated sepsis rising to 80 in those patients who go on to develop multiple organ failure so the number of deaths is considerable. The precise pathogenesis of sepsis-induced organ failure is unknown but changes that result in altered oxidative phosphorylation and ATP production occur in mitochondria. Mitochondrial production of reactive oxygen species Mitochondria are both the major source of intracellular reactive oxygen species ROS in a resting cell and a Correspondence Academic Unit of Anaesthesia Intensive Care School of Medicine Dentistry University of Aberdeen Aberdeen AB25 2ZD UK 2 BioMed Central 2010 BioMed Central Ltd major target 2 3 .