tailieunhanh - Báo cáo y học: " Early fluid resuscitation with hyperoncotic hydroxyethyl starch 200/0.5 (10%) in severe burn injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Early fluid resuscitation with hyperoncotic hydroxyethyl starch 200/ (10%) in severe burn injury. | Béchir et al. Critical Care 2010 14 R123 http content 14 3 R123 c CRITICAL CARE RESEARCH Open Access Early fluid resuscitation with hyperoncotic hydroxyethyl starch 200 10 in severe burn injury Markus Béchir 1 Milo A Puhan2 Simona B Neff3 Merlin Guggenheim4 Volker Wedler4 John F Stover1 Reto Stocker1 and Thomas A Neff1 Abstract Introduction Despite large experience in the management of severe burn injury there are still controversies regarding the best type of fluid resuscitation especially during the first 24 hours after the trauma. Therefore our study addressed the question whether hyperoncotic hydroxyethyl starch HES 200 10 administered in combination with crystalloids within the first 24 hours after injury is as effective as crystalloids only in severe burn injury patients. Methods 30 consecutive patients were enrolled to this prospective interventional open label study and assigned either to a traditional crystalloids only or to a HES 200 10 volume resuscitation protocol. Total amount of fluid administration complications such as pulmonary failure abdominal compartment syndrome sepsis renal failure and overall mortality were assessed. Cox proportional hazard regression analysis was performed for binary outcomes and adjustment for potential confounders was done in the multivariate regression models. For continuous outcome parameters multiple linear regression analysis was used. Results Group differences between patients receiving crystalloids only or HES 200 10 were not statistically significant. However a large effect towards increased overall mortality adjusted hazard ratio P in the HES 200 10 group as compared to the crystalloids only group versus was present. Similarly the incidence of renal failure was in the HES 200 10 group versus in the crystalloid only group adjusted hazard ratio P . Conclusions This small study indicates that the application of hyperoncotic HES 200 10 .