tailieunhanh - Báo cáo y học: "In-hospital percentage BNP reduction is highly predictive for adverse events in patients admitted for acute heart failure: the Italian RED Study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: In-hospital percentage BNP reduction is highly predictive for adverse events in patients admitted for acute heart failure: the Italian RED Study. | Di Somma et al. Critical Care 2010 14 R116 http content 14 3 R116 c CRITICAL CARE RESEARCH Open Access In-hospital percentage BNP reduction is highly predictive for adverse events in patients admitted for acute heart failure the Italian RED Study Salvatore Di Somma 1 Laura Magrini1 Valerio Pittoni1 Rossella Marino1 Antonella Mastrantuono1 Enrico Ferri1 Paola Ballarino2 Andrea Semplicini3 Giuliano Bertazzoni4 Giuseppe Carpinteri5 Paolo Mulè6 Maria Pazzaglia7 Kevin Shah8 Alan Maisel8 and Paul Clopton8 Abstract Introduction Our aim was to evaluate the role of B-type natriuretic peptide BNP percentage variations at 24 hours and at discharge compared to its value at admission in order to demonstrate its predictive value for outcomes in patients with acute decompensated heart failure ADHF . Methods This was a multicenter Italian 8 centers observational study Italian Research Emergency Department RED . 287 patients with ADHF were studied through physical exams lab tests chest X Ray electrocardiograms ECGs and BNP measurements performed at admission at 24 hours and at discharge. Follow up was performed 180 days after hospital discharge. Logistic regression analysis was used to estimate odds ratios OR for the various subgroups created. For all comparisons a P value was considered statistically significant. Results BNP median interquartile range IQR value at admission was 822 412 - 1390 pg mL at 24 hours was 593 270 - 1953 and at discharge was 325 160 - 725 . A BNP reduction of 46 at discharge had an area under curve AUC of P for predicting future adverse events. There were 78 events through follow up and in 58 of these patients the BNP level at discharge was 300 pg mL. A BNP reduction of after 24 hours had an AUC at ROC curve of for predicting adverse events P . The odds ratio of the patients whose BNP level at discharge was 300 pg mL and whose percentage decrease at discharge was 46 compared to the group whose BNP level at .