tailieunhanh - Báo cáo y học: "Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury. | Available online http content 13 6 R206 Open Access Research Argon Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury Philip D Loetscher1 Jan Rossaint1 Rolf Rossaint1 Joachim Weis2 Michael Fries3 Astrid Fahlenkamp1 Yu-Mi Ryang1 4 Oliver Grottke1 and Mark Coburn1 department of Anesthesiology University Hospital of the RWTH Aachen PauwelsstraBe 30 52074 Aachen Germany institute of Neuropathology University Hospital of the RWTH Aachen PauwelsstraBe 30 52074 Aachen Germany department of Surgical Intensive Care University Hospital of the RWTH Aachen PauwelsstraBe 30 52074 Aachen Germany department of Neurosurgery University Hospital of the RWTH Aachen PauwelsstraBe 30 52074 Aachen Germany Corresponding author Mark Coburn mcoburn@ Received 22 Oct 2009 Revisions requested 12 Nov 2009 Revisions received 23 Nov 2009 Accepted 17 Dec 2009 Published 17 Dec 2009 Critical Care 2009 13 R206 doi cc8214 This article is online at http content 13 6 R206 2009 Loetscher et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Recently it has been shown in several experimental settings that the noble gases xenon and helium have neuroprotective properties. In this study we tested the hypothesis that the noble gas argon has a neuroprotective potential as well. Since traumatic brain injury and stroke are widespread and generate an enormous economic and social burden we investigated the possible neuroprotective effect in in vitro models of traumatic brain injury and cerebral ischemia. Methods Organotypic hippocampal slice cultures from mice pups were subjected to either oxygen-glucose deprivation or to a focal mechanical trauma and subsequently treated .