tailieunhanh - Báo cáo y học: "Comparison of albicans vs. non-albicans candidemia in French intensive care units."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of albicans vs. non-albicans candidemia in French intensive care units. | Leroy et al. Critical Care 2010 14 R98 http content 14 3 R98 RESEARCH Open Access Comparison of albicans vs. non-albicans candidemia in French intensive care units Olivier Leroy 1 Jean-Paul Mira2 3 Philippe Montravers4 5 Jean-Pierre Gangneux6 7 Olivier Lortholary8 9 10 for the AmarCand Study Group Abstract Introduction Candidemia raises numerous therapeutic issues for intensive care physicians. Epidemiological data that could guide the choice of initial therapy are still required. This analysis sought to compare the characteristics of intensive care unit ICU patients with candidemia due to non-albicans Candida species with those of ICU patients with candidemia due to Candida albicans. Methods A prospective observational multicenter French study was conducted from October 2005 to May 2006. Patients exhibiting candidemia developed during ICU stay and exclusively due either to one or more non-albicans Candida species or to C. albicans were selected. The data collected included patient characteristics on ICU admission and at the onset of candidemia. Results Among the 136 patients analyzed 78 had candidemia caused by C. albicans. These patients had earlier onset of infection days after ICU admission vs. p higher severity scores on ICU admission SOFA vs. p SAPS II vs. P and were less often neutropenic vs. 12 p than patients with candidemia due to non-albicans Candida species. Conclusions Although patients infected with Candida albicans differed from patients infected with non-albicans Candida species for a few characteristics no clinical factor appeared pertinent enough to guide the choice of empirical antifungal therapy in ICU. Introduction The importance of fungal infections in Intensive Care Units ICUs was recently underlined by the EPIC Study II since fungal agents represented 19 of positive isolates 1 . Moreover candidemia still raises numerous therapeutic issues to .