tailieunhanh - Báo cáo y học: "Leptin in sepsis: a well-suited biomarker in critically ill patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Leptin in sepsis: a well-suited biomarker in critically ill patients? | Bracho-Riquelme and Reyes-Romero Critical Care 2010 14 138 http content 14 2 138 CRITICAL CARE COMMENTARY L__ Leptin in sepsis a well-suited biomarker in critically ill patients Rodolfo Leonel Bracho-Riquelme 1 2 and Miguel Arturo Reyes-Romero 1 See related research by Yousef etal. http content 14 2 R33 Abstract The value of monitoring serum leptin in critically ill patients is important for early diagnosis and differentiation between sepsis and non-infectious systemic inflammatory response syndrome SIRS . The early diagnosis of sepsis the identification of its origin and an adequate therapeutic management are crucial to overcome sepsis-associated mortality. Cytokine levels are an obvious choice as sepsis markers since cytokines are key mediators of the inflammatory response to sepsis. Leptin a hormone mainly generated by adipocytes acts centrally in the hypothalamus to regulate body weight and energy expenditure. There is however strong evidence that leptin is also involved in cell-mediated immunity and cytokine crosstalk. The finding that a serum leptin threshold of 38 pg l can distinguish between sepsis and non-infectious SIRS sensitivity specificity 85 is the major finding in the article by Yousef and colleagues in this issue . Much remains to be learned about the precise mechanisms by which leptin signaling participates in sepsis and non-infectious SIRS. This knowledge will potentially contribute to new therapeutic approaches. Yousef and colleagues article discussing the value of monitoring serum leptin in critically ill patients touches on the important matter of early diagnosis and differentiation between sepsis and non-infectious systemic inflammatory response syndrome SIRS 1 . The early diagnosis of sepsis the identification of its origin and an adequate therapeutic management are crucial to overcome sepsis-associated mortality 2 . Correspondence rudybracho@ 1Universidad Juarez del Estado de Durango .