tailieunhanh - Báo cáo y học: " CD4+ lymphocyte adenosine triphosphate determination in sepsis: a cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: CD4+ lymphocyte adenosine triphosphate determination in sepsis: a cohort study. | Lawrence et al. Critical Care 2010 14 R110 http content 14 3 R110 c CRITICAL CARE RESEARCH Open Access CD4 lymphocyte adenosine triphosphate determination in sepsis a cohort study Kevin L Lawrence1 Patrick H White1 Gerald P Morris2 Jody Jennemann3 Donna L Phelan3 Richard S Hotchkiss4 and Marin H Kollef 1 Abstract Introduction Patients suffering from sepsis are currently classified on a clinical basis . sepsis severe sepsis septic shock however this clinical classification may not accurately reflect the overall immune status of an individual patient. Our objective was to describe a cohort of patients with sepsis in terms of their measured immune status. Methods Fifty-two patients with sepsis n 13 severe sepsis n 21 or septic shock n 18 were studied. The immune status was determined by measuring the CD4 lymphocyte adenosine triphosphate ATP content after mitogen stimulation in whole blood. Results The measured CD4 lymphocyte ATP content at the time of ICU admission did not differ among the various groups defined by the sepsis classification system sepsis 454 79 ng ml severe sepsis 359 54 ng ml septic shock 371 53 ng ml P . Furthermore survivors of sepsis had a significantly higher CD4 lymphocyte ATP content at the time of ICU admission than did nonsurvivors of sepsis 431 41 ng mL vs. 266 53 ng mL respectively P . Conclusions The sepsis classification system that is currently used is not representative of the individual immune status as determined by measuring the CD4 lymphocyte ATP content. Moreover a lower CD4 ATP content at the time of ICU admission is associated with a worse clinical outcome in those suffering from sepsis. Introduction Sepsis the systemic inflammatory response syndrome that results from infection is associated with considerable mortality. Besides controlling the inciting infectious insult and providing good supportive care few therapies are available to treat this syndrome. Although it seems conceptually appealing that .

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