tailieunhanh - Báo cáo y học: "Activated protein C for H1N1 influenza? More work to do"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Activated protein C for H1N1 influenza? More work to do! | LaRosa Critical Care 2010 14 156 http content 14 3 156 CRITICAL CARE COMMENTARY L__ Activated protein C for H1N1 influenza More work to do Steven P LaRosa See related research by Schouten etal. http content 14 2 R65 Abstract An animal model of H1N1 influenza demonstrates that this infection is associated with pulmonary and systemic activation of coagulation and impairment of fibrinolysis in addition to systemic inflammation and intense neutrophil influx into the lung. Activated protein C attenuates coagulation activation and restores fibrinolytic capacity but has little effect on inflammation or survival from this infection. This animal model points to a profound inflammatory state developing in H1N1 infection that impacts mortality. Additional modifications to the model and the type and amount of activated protein C dosing will provide the data to determine the possible use of activated protein C as a therapy in human H1N1 infection. In 2009 the seasonal influenza virus was replaced with a pandemic H1N1 infection strain swine flu . Since that time numerous reports have surfaced of severe disease occurring and resulting in acute lung injury and mortality. Treatment of this infection has involved oselta-mavir and supportive care. A logical next step would be to find an adjuvant agent that could be of benefit in severe disease. To discover this agent one must first understand the pathogenesis of this unique virus. In the previous issue of Critical Care Schouten and colleagues attempt to build on the knowledge gained about the pathogenesis of H1N1 in a lethal mouse model 1 . These authors ask two questions. Does viral pneumonia due to H1N1 cause sytemic and pulmonary activation of coagulation and inhibition of fibrinolysis in the lungs similar to what is known to occur in community-acquired bacterial pneumonia and acute respiratory Correspondence slarosa@ Division of Infectious Disease Rhode Island Hospital Alpert School of