tailieunhanh - Báo cáo y học: "Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study. | Meierhenrich et al. Critical Care 2010 14 R108 http content 14 3 R108 c CRITICAL CARE RESEARCH Open Access Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock a prospective observational study Rainer Meierhenrich Elisa Steinhilber Christian Eggermann Manfred Weiss Sami Voglic Daniela Bogelein Albrecht Gauss Michael Georgieff and Wolfgang Stahl Abstract Introduction Since data regarding new-onset atrial fibrillation AF in septic shock patients are scarce the purpose of the present study was to evaluate the incidence and prognostic impact of new-onset AF in this patient group. Methods We prospectively studied all patients with new-onset AF and all patients suffering from septic shock in a non-cardiac surgical intensive care unit ICU during a 13 month period. Results During the study period 687 patients were admitted to the ICU of which 58 patients were excluded from further analysis due to pre-existing chronic or intermittent AF. In 49 out of the remaining 629 patients new-onset AF occurred and 50 out of the 629 patients suffered from septic shock. 23 out of the 50 patients with septic shock 46 developed new-onset AF. There was a steady significant increase in C-reactive protein CRP levels before onset of AF in septic shock patients. ICU mortality in septic shock patients with new-onset AF was 10 23 44 compared with 6 27 22 in septic shock patients with maintained sinus rhythm SR P . During a 2-year follow-up there was a trend towards an increased mortality in septic shock patients with new-onset AF but the difference did not reach statistical significance P . The median length of ICU stay among surviving patients was longer in patients with new-onset AF compared to those with maintained SR 30 versus 17 days P . The success rate to restore SR was 86 . Failure to restore SR was associated with increased ICU mortality versus P . Conclusions AF is a common complication in septic