tailieunhanh - Báo cáo y học: " Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection. | Dickinson and Franks Critical Care 2010 14 229 http content 14 4 229 CRITICAL CARE REVIEW L_ Bench-to-bedside review Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection Robert Dickinson - 2 and Nicholas P Franks -2 Abstract In the past decade there has been a resurgence of interest in the clinical use of inert gases. In the present paper we review the use of inert gases as anesthetics and neuroprotectants- with particular attention to the clinical use of xenon. We discuss recent advances in understanding the molecular pharmacology of xenon and we highlight specific pharmacological targets that may mediate its actions as an anesthetic and neuroprotectant. We summarize recent in vitro and in vivo studies on the actions of helium and the other inert gases and discuss their potential to be used as neuroprotective agents. Introduction The inert or noble gases helium neon argon krypton and xenon exist as monatomic gases with low chemical reactivity. Considerable attention has focused on the use of xenon as a general anesthetic 1-4 and its potential for use as a neuroprotectant 5-7 . A number of recent studies report that helium may have neuroprotectant and or cardioprotecant properties 8-13 . Argon also appears to be neuroprotective in certain in vitro and in vivo models 14 15 . At first sight it might appear unlikely that inert gases would have any biological activity. Nevertheless evidence for the biological effects of inert gases emerged from research into the physiological effects of diving. As long ago as the 1930s nitrogen was shown to be the cause of the narcosis experienced by divers 16 17 . The narcotic effects of nitrogen begin to occur at a depth of about 30 meters a pressure of 3 atm and increased with depth with loss Correspondence Biophysics Section Blackett Laboratory Imperial College London South Kensington London SW7 2AZ UK Full list of author information is available at .