tailieunhanh - Báo cáo y học: " Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury? | Matejovic and Radermacher Critical Care 2010 14 147 http content 14 3 147 CRITICAL CARE COMMENTARY L__ Pulmonary and renal protection targeting PARP to ventilator-induced lung and kidney injury Martin Matejovic 1 and Peter Radermacher2 See related research by Vaschetto etal. http content 14 2 R45 Abstract Both acute lung injury and acute kidney injury AKI are frequent and serious problems in intensive care medicine. Therefore the avoiding of any iatrogenic insult to these organs is of great importance. While an increasing body of evidence suggests that mechanical ventilation is capable of inducing lung and distant organ injury the complex underlying molecular mechanisms remain insufficiently understood. In the previous issue of Critical Care Vaschetto and colleagues reported the results of an experimental study designed to further explore pathways linking injurious ventilation with AKI. The authors demonstrated that scavenging of peroxynitrite or inhibiting poly ADP-ribose polymerase PARP afforded protection against AKI induced by double-hit lung injury. Although PARP inhibition or peroxynitrite detoxification or both may become viable candidates for a protective strategy in this setting the implementation of a lung-protective ventilatory strategy remains the only clinical tool to mitigate the lung biotrauma and its systemic consequences. In the previous issue of Critical Care Vaschetto and colleagues 1 sought to determine whether and by which mechanism s the activation of poly ADP-ribose polymerase PARP contributes to the acute kidney injury AKI induced by injurious mechanical ventilation MV . The authors used a double-hit rat model of acute lung injury comprising lipopolysaccharide-induced lung inflammation and MV with either very high tidal volume 19 mL kg zero positive end-expiratory pressure PEEP or low tidal volume 6 mL kg PEEP 5 cm H2O . To address the role of peroxynitrite and PARP in mediating MV-induced Correspondence .