tailieunhanh - Báo cáo y học: "Th17 mediators and vitamin D status"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Th17 mediators and vitamin D status. | Krstic Critical Care 2010 14 410 http content 14 2 410 CRITICAL CARE LETTER L_ Th17 mediators and vitamin D status Goran Krstic See related research by Bermejo-Martin etal. http content 13 6 R201 In their study on 1111 and Th17 hypercytokinemia in severe pandemic influenza Bermejo-Martin and colleagues 1 observed significantly elevated levels of IL-17 and particularly IL-6 in critically ill patients. They also reported that up to 50 of critical care patients studied were obese. Correale and colleagues 2 indicate that activated vitamin D enhances the development of IL-10-producing cells and reduces the number of IL-6- and IL-17-secreting cells. Studies show that obese and overweight individuals are more likely to have an inadequate vitamin D status 3 4 . According to Louie and colleagues 5 diabetes and obesity were the most frequently identified underlying conditions in fatal pandemic 2009 influenza A H1N1 infection cases older than age 20 years worldwide. In addition obese people usually have high calorie and low nutritional value diets. Aasheim and colleagues 6 showed that low concentrations of vitamin B-6 vitamin C 25-hydroxyvitamin D and vitamin E adjusted for lipids are prevalent in morbidly obese Norwegian patients seeking weight-loss treatment. It would be interesting to see if any of the critical cases observed in the study by Bermejo-Martin and colleagues were insufficient or deficient in vitamin D and or other nutrients relevant for intracellular signaling involved in inflammation. If vitamin D plays a role in human general capacity to deal with infection and other diseases then an increase in Th17 mediators in severe pandemic influenza patients could be at least in part related to vitamin D insufficiency deficiency. Authors response Jesus F Bermejo-Martin and the SEMICYUC H1N1 working group We appreciate Dr Krstic s comment on our article on Th1-Th17 hypercytokinemia in severe pandemic influenza recently published in Critical

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