tailieunhanh - Báo cáo y học: "First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1. | Fernandez de Castro et al. Critical Care 2010 14 115 http content 14 1 115 CRITICAL CARE COMMENTARY L__ First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1 Isabel Fernandez de Castro María Guzman-Fulgencio Mónica García-Álvarez and Salvador Resino See related research by Bermejo-Martin etal. http content 13 6 R201 Abstract The great majority of infections caused by the pandemic variant of the influenza virus nvH1N1 are self-limited but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early immune response for patients both mildly and severely infected with nvH1N1. Patients who develop severe symptoms after nvH1N1 infection showed Th1 and Th17 hypercytokinemia compared to mildly infected patients and healthy controls. The mediators involved with the Th1 and Th17 profiles are known to be involved in antiviral pro-inflammatory and autoimmune responses. This is the first work reporting the association of a pro-inflamatory immune response with a severe pandemic infection although it is likely that more studies are needed to understand the detrimental or beneficial roles these cytokines play in the evolution of mild and severe nvH1N1 infection. In a recent article for Critical Care Bermejo-Martin and colleagues 1 describe 1111 and Th17 hypercytokinemia as an early signature host response to severe infection by the pandemic variant of the influenza virus nvH1N1 . The nvH1N1 infection is usually self-limiting in nature but some patients develop severe symptoms requiring hospitalization 2 . The host immune response may play an important role in poor outcomes after infection. The human host immune response to nvH1N1 infection is unknown at this time and studies on its contribution to disease pathogenesis are desperately needed to improve prevention and treatment strategies. .

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