tailieunhanh - Báo cáo y học: "Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs: an investigation based on a viscoelastic model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs: an investigation based on a viscoelastic model. | Available online http content 13 6 R199 Research Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs an investigation based on a viscoelastic model Steven Ganzert1 Knut Moller2 Daniel Steinmann1 Stefan Schumann1 and Josef Guttmann1 Open Access 1 Department of Anesthesiology and Critical Care Medicine University Medical Center Freiburg Hugstetter Str. 55 D-79106 Freiburg Germany 2Department of Biomedical Engineering Furtwangen University Villingen-Schwenningen Campus Jakob Kienzle Str. 1 7 D-78054 Villingen-Schwenningen Germany Corresponding author Steven Ganzert Received 10 Jul 2009 Revisions requested 14 Sep 2009 Revisions received 1 7 Nov 2009 Accepted 9 Dec 2009 Published 9 Dec 2009 Critical Care 2009 13 R199 doi cc8203 This article is online at http content 13 6 R1 99 2009 Ganzert et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Limiting the energy transfer between ventilator and lung is crucial for ventilatory strategy in acute respiratory distress syndrome ARDS . Part of the energy is transmitted to the viscoelastic tissue components where it is stored or dissipates. In mechanically ventilated patients viscoelasticity can be investigated by analyzing pulmonary stress relaxation. While stress relaxation processes of the lung have been intensively investigated non-linear interrelations have not been systematically analyzed and such analyses have been limited to small volume or pressure ranges. In this study stress relaxation of mechanically ventilated lungs was investigated focusing on non-linear dependence on pressure. The range of inspiratory capacity was analyzed up to a plateau .