tailieunhanh - Báo cáo y học: "Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding. | Available online http content 13 6 R191 Research Prothrombin complex concentrate in surgical patients retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding Kerstin S Schick Jan M Fertmann Karl-Walter Jauch and Johannes N Hoffmann Open Access Department of Surgery University of Munich - GroBhadern Marchioninistrasse 15 81377 Munich Germany Corresponding author Johannes N Hoffmann Received 8 Jul 2009 Revisions requested 27 Aug 2009 Revisions received 13 Nov 2009 Accepted 30 Nov 2009 Published 30 Nov 2009 Critical Care 2009 13 R191 doi cc8186 This article is online at http content 13 6 R1 91 2009 Schick et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Prothrombin complex concentrates are recommended for rapid reversal of vitamin K anticoagulants. As they normalize levels of vitamin K dependent clotting factors and re-establish hemostasis they may also be used as adjunctive therapy in patients with major bleeding. The aim of this study was to retrospectively evaluate the efficacy of prothrombin complex concentrates in the surgical setting. Methods The case notes of 50 patients requiring urgent oral anticoagulation reversal n 12 or with severe perioperative coagulopathic bleeding n 38 who received an infusion of prothrombin complex concentrate Beriplex P N R 500 at the surgical department of the University of Munich Hospital Germany were retrospectively reviewed. Efficacy of prothrombin complex concentrate application was evaluated using the Quick test reported as an international normalized ratio hemodynamic measurements and requirement for blood products. Safety assessments included whole blood