tailieunhanh - Báo cáo y học: "Angiotensin II in experimental hyperdynamic sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Angiotensin II in experimental hyperdynamic sepsis. | Available online http content 13 6 R190 Open Access Angiotensin II in experimental hyperdynamic sepsis Li Wan1 2 3 4 Christoph Langenberg1 Rinaldo Bellomo2 3 and Clive N May1 1Howard Florey Institute University of Melbourne Grattan Street Parkville Melbourne Victoria 3052 Australia 2Australian and New Zealand Intensive Care Research Centre Department of Epidemiology and Preventive Medicine Monash University Burnett Building Commercial Road Prahran Melbourne Victoria Australia 3Department of Intensive Care and Department of Medicine Austin Health Studley Road Heidelberg Melbourne Victoria 3084 Australia 4Department of Pharmacology University of Melbourne Grattan Street Parkville Melbourne Victoria 3052 Australia Corresponding author Rinaldo Bellomo Received 1 Oct 2009 Revisions requested 2 Nov 2009 Revisions received 12 Nov 2009 Accepted 30 Nov 2009 Published 30 Nov 2009 Critical Care 2009 13 R190 doi cc8185 This article is online at http content 13 6 R1 90 2009 Wan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Angiotensin II Ang II is a potential vasopressor treatment for hypotensive hyperdynamic sepsis. However unlike other vasopressors its systemic regional blood flow and renal functional effects in hypotensive hyperdynamic sepsis have not been investigated. Methods We performed an experimental randomised placebo-controlled animal study. We induced hyperdynamic sepsis by the intravenous administration of live E. coli in conscious ewes after chronic instrumentation with flow probes around the aorta and the renal mesenteric coronary and iliac arteries. We allocated animals to either placebo or angiotensin II infusion titrated to .