tailieunhanh - Báo cáo y học: "Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation. | Available online http content 13 6 R189 Research Measurement of tissue cortisol levels in patients with severe burns a preliminary investigation Jeremy Cohen1 Renae Deans1 Andrew Dalley1 Jeff Lipman1 Michael S Roberts2 and Bala Venkatesh3 1Burns Trauma and Critical Care Research Centre University of Queensland Butterfield St Herston 4006 Australia 2Therapeutic Research Unit University of Queensland Princess Alexandra Hospital Ipswich Rd Woolloongabba Queensland 4102 Australia intensive Care Unit Princess Alexandra Hospital and Wesley Hospitals University of Queensland Ipswich Road 41 02 Auchenflower Australia Corresponding author Jeremy Cohen jeremy_cohen@ Received 23 Jul 2009 Revisions requested 2 Sep 2009 Revisions received 7 Oct 2009 Accepted 27 Nov 2009 Published 27 Nov 2009 Critical Care 2009 13 R189 doi cc8184 This article is online at http content 13 6 R1 89 2009 Cohen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The assessment of adrenal function in critically ill patients is problematic and there is evidence to suggest that measurement of tissue glucocorticoid activity may be more useful than estimation of plasma cortisol concentrations. Interstitial cortisol concentrations of cortisol represent the available pool of glucocorticoids able to enter the cell and bind to the glucocorticoid receptor. However the concentrations of plasma cortisol may not accurately reflect interstitial concentrations. We elected to perform a preliminary study into the feasibility of measuring interstitial cortisol by microdialysis and to investigate the relationship between total plasma cortisol free plasma cortisol and interstitial cortisol in .