tailieunhanh - Báo cáo y học: "Clinical review: Primary influenza viral pneumonia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical review: Primary influenza viral pneumonia. | Available online http content 13 6 235 Review Clinical review Primary influenza viral pneumonia Jordi Rello1 and Aurora Pop-Vicas2 Critical Care Department Joan XXIII University Hospital CIBERES Enfermedades Respiratorias IISPV Mallafre Guasch 4 43007 Tarragona Spain 2Division of Infectious Disease Memorial Hospital of Rhode Island 111 Brewster Street Pawtucket RI 02860 USA Corresponding author Aurora Pop-Vicas Aurora_Pop-Vicas@ Published 21 December 2009 This article is online at http content 13 6 235 2009 BioMed Central Ltd Critical Care 2009 13 235 doi cc8183 Abstract Primary influenza pneumonia has a high mortality rate during pandemics not only in immunocompromised individuals and patients with underlying comorbid conditions but also in young healthy adults. Clinicians should maintain a high index of suspicion for this diagnosis in patients presenting with influenza-like symptoms that progress quickly 2 to 5 days to respiratory distress and extensive pulmonary involvement. The sensitivity of rapid diagnostic techniques in identifying infections with the pandemic 2009 H1N1v influenza strain is currently suboptimal. The most reliable real-time reverse transcriptase-polymerase chain reaction molecular testing is available in limited clinical settings. Despite 6 months of pandemic circulation most novel H1N1v pandemic strains remain susceptible to oseltamivir. Ensuring an appropriate oxygenation and ventilation strategy as well as prompt initiation of antiviral therapy is essential in management. Introduction As the novel swine-origin influenza A H1N1 v global pandemic is under way the medical community has already experienced an increase in hospitalizations from influenza-related complications in many geographic regions. Primary viral pneumonia is recognized as the most severe pulmonary manifestation of influenza. While uncommon during seasonal epidemics the syndrome has been well documented during the H2N2 pandemic of .