tailieunhanh - Báo cáo hóa học: " Research Article Short Exon Detection in DNA Sequences Based on Multifeature Spectral Analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Short Exon Detection in DNA Sequences Based on Multifeature Spectral Analysis | Hindawi Publishing Corporation EURASIP Journal on Advances in Signal Processing Volume 2011 Article ID 780794 8 pages doi 2011 780794 Research Article Short Exon Detection in DNA Sequences Based on Multifeature Spectral Analysis Nancy Yu Song and Hong Yan Department of Electronic Engineering City University of Hong Kong Kowloon Hong Kong Correspondence should be addressed to Nancy Yu Song 50728680@ Received 30 June 2010 Revised 26 August 2010 Accepted 31 October 2010 Academic Editor Antonio Napolitano Copyright 2011 N. Y. Song and H. Yan. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. This paper presents a new technique for the detection of short exons in DNA sequences. In this method we analyze four DNA structural properties which include the DNA bending stiffness disrupt energy free energy and propeller twist using the autoregressive AR model. The linear prediction matrices for the four features are combined to find the same set of linear prediction coefficients from which we estimate the spectrum of the DNA sequence and detect exons based on the 1 3 frequency component. To overcome the nonstationarity of DNA sequences we use moving windows of different sizes in the AR model. Experiments on the human genome show that our multi-feature based method is superior in performance to existing exon detection algorithms. 1. Introduction Signals converted from DNA sequence are nonstationary. The coding sequence of a prokaryotic gene is a contiguous series of three-nucleotide codons. The codon for one amino acid is immediately adjacent to the codon for the next amino acid in the polypeptide chain. However this may not be the case for eukaryotic genes. Many eukaryotic genes comprise blocks of exons from each other by blocks of intons. The exons contain protein-coding instructions. .