tailieunhanh - Báo cáo y học: " Hepatitis G Virus associated aplastic anemia: A recent case from Pakistan"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hepatitis G Virus associated aplastic anemia: A recent case from Pakistan | Riaz Shah et al. Virology Journal 2011 8 30 http content 8 1 30 J VIROLOGY JOURNAL SHORT REPORT Open Access Hepatitis G Virus associated aplastic anemia A recent case from Pakistan Shahida Amjad Riaz Shah1 Muhammad Idrees2 Abrar Hussain2 Abstract Background Aplastic anemia AA is a serious and rare disorder characterized by a hypocellular bone marrow. Hepatitis associated aplastic anemia HAAA is a variant of aplastic anemia in which aplastic anemia follows an acute attack of hepatitis. Several reports have noted an association between HGV and hepatitis-associated aplastic anemia besides other hepatitis causing viruses. Case presentation A female girl of age 11 year with a history of loose motion for one month vomiting for last 15 days and poor oral intake for last few days is reported here. The physical examination presents fever pallor whereas bleeding hepatomegaly Splenomegaly and bruising were absent abdominal ultrasonography confirmed the absence of hepatomegaly Splenomegaly and lymphodenopathy. The laboratory investigation parameters were haemoglobin g L total leucocytes count neutrophils absolute reticulocyte count Monocytes red cell count mil uL Picked cell volume PCV Mean Corpuscular Volume MCV 78 fL Mean Corpuscular Hemoglobin MCH pg. The liver enzymes were alanine aminotransferease ALT 98 IU L aspartate aminotransferase AST 114 IU L. Serologic and molecular tests for hepatitis A B C D E TTV B19 were negative whereas HGV RNA PCR test was found positive for hepatitis G virus. The bone marrow aspirate and trephine biopsy examination revealed hypo- cellularity erythropoiesis myelopoiesis and megakaryopoiesis. Conclusion HAAA is an uncommon but severe condition which may occur following idiopathic cases of acute hepatitis. Our finding suggests the involvement of HGV in the development of aplastic anemia. In patients presenting with pancytopenia after an episode of acute hepatitis the definitive diagnosis .