tailieunhanh - Báo cáo y học: " An overview of treatment response rates to various anti-viral drugs in Pakistani Hepatitis B Virus infected patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: An overview of treatment response rates to various anti-viral drugs in Pakistani Hepatitis B Virus infected patients | Ali et al. Virology Journal 2011 8 20 http content 8 1 20 J VIROLOGY JOURNAL REVIEW Open Access An overview of treatment response rates to various anti-viral drugs in Pakistani Hepatitis B Virus infected patients Liaqat Ali Muhammad Idrees Muhammad Ali Irshad-ur Rehman Abrar Hussain Samia Afzal Sadia Butt Sana Saleem Saira Munir Sadaf Badar Abstract Hepatitis B virus HBV is one of the leading health problem with up to 350 million affected people worldwide including million only in Pakistan. It has mortality rate of to million per year worldwide. Pakistan lies in the endemic region with 3-5 HBV carrier rate in the country. The present article reviews the literature on the treatment response of HBV prevalent in Pakistani population. The average treatment response of Lamivudine and interferon-a is and respectively. Peg-Interferon was shown to be not effective against the HBV HCV hepatitis C virus HDV hepatitis Delta virus co-infection. The present study reveals that interferon-a is the most effective therapy available for HBV infection prevalent in Pakistani population. Genotype C D are the most common HBV genotypes in Pakistan and are associated with increased severity and less response to interferon therapy. This poses a great challenge for physicians and researchers and further studies are needed to describe the outcome of the current therapies recommended against HBV infection in Pakistani population. Introduction Hepatitis B virus HBV is a crucial health problem with up to 350 million affected people worldwide 1 . HBV is a member of the Hepadnaviridae family with kilobase pair DNA genome which is partially doublestranded 2 3 . Pre-s domain surface protein is mediates its attachment to the cell membrane 4 . Several previous studies on the association of the HBV genotypes with disease progression reported that genotypes B and C are correlated with severity of liver dysfunction while high viral loads were observed in .