tailieunhanh - Báo cáo y học: "Carbamazepine overdose after exposure to simethicone: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Carbamazepine overdose after exposure to simethicone: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Carbamazepine overdose after exposure to simethicone a case report Ozlem Guneysel Ozge Onur Arzu Denizbasi and Murat Saritemur Address Marmara University School of Medicine Department of Emergency Medicine Istanbul Turkey Email Ozlem Guneysel - guneysel@ Ozge Onur-ozberkozge@ Arzu Denizbasi - denizbasi@ Murat Saritemur - muratsaritemur@ Corresponding author Published 24 July 2008 Received 12 November 2007 Journal of Medical Case Reports 2008 2 242 doi 1752-1947-2-242 Accepted 24 July 2008 This article is available from http content 2 1 242 2008 Guneysel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Introduction Carbamazepine is an anticonvulsant drug and is also used as a treatment for patients with manic-depressive illness post-herpetic neuralgia or phantom limb pain. The drug itself has many drug interactions. Simethicone is an antifoaming agent and is reported to be an inert material with no known drug interaction with carbamazepine. Case presentation We present a case of a patient who was routinely using carbamazepine 400 mg three times per day and levetiracetam 500 mg twice daily and experienced carbamazepine overdose after exposure to simethicone. After cessation of simethicone therapy normal drug levels of carbamazepine were obtained again with the standard dose of the drug. The mechanism of interaction is unknown but the risk of overdose should be considered when prescribing simethicone to a patient who is using carbamazepine. Conclusion Simethicone and carbamazepine when taken .