tailieunhanh - Báo cáo y học: " Human Papillomavirus in Brazilian women with and without cervical lesions"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Human Papillomavirus in Brazilian women with and without cervical lesions | Oliveira-Silva et al. Virology Journal 2011 8 4 http content 8 1 4 J VIROLOGY JOURNAL RESEARCH Open Access Human Papillomavirus in Brazilian women with and without cervical lesions Michelle Oliveira-Silva1 Camila X l_ordello2 3 Lucília MG Zardo4 Cibele R Bonvicino1 3 Miguel AM Moreira3 Abstract Background Human Papillomavirus HPV high-risk HR types are the causal factor for cervical cancer and premalignant dysplasia. Data on frequency of HPV types provide a basis to design and evaluate HPV prevention programs. Taking into account the heterogeneity of HPV types across and within populations this study aims to access the HPV frequency in Brazilian women. Results We identified 24 different types of HPV including a Betapapillomavirus and a likely new type previously reported from 132 women positive for the virus analysed by Hybrid Capture II assay. These women were infected by a single or multiple HPV types and 142 HPV strains were identified. HR types were found in 75 of women and HPV types 16 18 45 58 and 66 had the highest frequency. Significant differences in frequency of HR HPV types were found for presence of cervical lesions and for different HPV species and women age. Conclusions Compared with previous studies in Brazil our data indicated differences in frequency and HPV type diversity a significant association of other HR-types but HPV16 and 18 and cervical lesions and a trend for distinct distribution of HPV types by age. Background Cervical cancer accounts for the third highest mortality amongst cancers in women worldwide with a higher incidence and frequency in underdeveloped and developing countries 1 . The etiology of cervical cancer attributed to the high-risk types HR of Human Papillomavirus HPV has been well established by experimental and epidemiological studies 2-4 . Due to the discovery of more than 100 HPV types and the association of some types with cancer pre-cancerous lesions and genital warts 5 a series of assays based on .