tailieunhanh - Báo cáo y học: " Association between nasal shedding and fever that influenza A (H3N2) induces in dogs"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Association between nasal shedding and fever that influenza A (H3N2) induces in dogs | Song et al. Virology Journal 2011 8 1 http content 8 1 1 J VIROLOGY JOURNAL RESEARCH Open Access Association between nasal shedding and fever that influenza A H3N2 induces in dogs Daesub Song1 2t Hyoungjoon Moon2t Kwonil Jung6 Minjoo Yeom 2 Hyekwon Kim3 Sangyoon Han2 Dongjun An4 Jinsik Oh5 Jongman Kim2 Bongkyun Park3 Bokyu Kang2 Abstract Background Avian origin canine influenza virus was reported in Korea. The dog to dog contact transmission of the avian origin canine influenza virus CIV H3N2 and CIV H3N8 was shown by experimental contact transmission. This study was focused on viral excretion and fever in order to elucidate the epidemiological associations which might be helpful to control the disease transmissions in CIV outbreak in dogs. Methods An influenza seronegative 10-week-old Beagle dog was experimentally inoculated with the canine influenza virus A canine 01 2007 subtype H3N2. Eight hours after inoculation the infected dog was cohoused with seven uninfected Beagle dogs. Clinical signs including fever were recorded for 14 days post inoculation. Results The infected dog and four of seven contact dogs in the study showed clinical signs sneezing nasal discharge and coughing during the study. Viral shedding occurred in all of the animals tested and began on 1 to 6 DPI in dogs with clinical signs. Elevated body temperatures above C geometric mean temperature of C were observed in all symptomatic dogs. The mean viral titer during fever was log EID50 ml which was significantly higher than the viral titer detected in the non fever. Conclusions The data show that contact dogs with a canine influenza infected dog shed different levels of virus in their nasal excretions and demonstrate that clinical signs including fever significantly correlate with the viral shedding. Background Canine influenza virus infection caused severe and acute respiratory symptoms in infected dogs 1-4 . Especially avian origin canine influenza virus .