tailieunhanh - Báo cáo y học: "Unraveling the role of high mobility group box protein 1 in severe traum"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Unraveling the role of high mobility group box protein 1 in severe trauma. | Available online http content 13 6 1004 Commentary Unraveling the role of high mobility group box protein 1 in severe trauma Edward Abraham Department of Medicine University of Alabama at Birmingham Birmingham AL 35294 USA Corresponding author Edward Abraham eabraham@ See related research by Cohen et al. http content 13 6 R174 Published 12 November 2009 This article is online at http content 13 6 1004 2009 BioMed Central Ltd Critical Care 2009 13 1004 doi cc8141 Abstract High mobility group box protein 1 HMGB1 has been shown to participate in acute inflammatory reactions including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflam-matory activity but is able to potentiate inflammatory responses through binding to mediators such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether inhibition of interactions of HMGB1 and associated molecules with the cell surface can affect outcome after trauma. High mobility group box protein 1 HMGB1 has long been known to participate as a nuclear cofactor in the regulation of transcriptional events. However over the past several years HMGB1 has been demonstrated to be secreted by cells such as macrophages activated by lipopolysaccharide and other mediators associated with sepsis and acute inflammatory processes. A study that now appears in Critical Care not only shows that plasma HMGB1 levels are elevated within less than an hour after severe trauma but also reports an association between HMGB1 levels and severity of injury and survival 1 . These results are consistent with those previously reported in which serum concentrations of HMGB1 were found to be increased within 1 .