tailieunhanh - Báo cáo y học: "Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit/Hyperactivity Disorder core symptoms: Meta-analysis of five atomoxetine trials. | Wehmeier et al. Child and Adolescent Psychiatry and Mental Health 2010 4 30 http content 4 1 30 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH RESEARCH Open Access Differences between children and adolescents in treatment response to atomoxetine and the correlation between health-related quality of life and Attention Deficit Hyperactivity Disorder core symptoms Meta-analysis of five atomoxetine trials Pdtdr l l A dhmdidr1 2A ŨI C H .K Hf PccctH r c 1 i 4 I rr iio5 reter M Wei III lelel Alexdnder scildcilt nuuiigu Escobdr INicold Sdvill Vdl ndipill Abstract Objectives To explore the influence of dge on tredtment responses to dtumuxetine dnd to dssess the reldtionship between core symptoms of dttention deficit hyperdctivity disorder ADHD dnd hedlth-reldted qudlity of life HR-QoL outcomes. Data Sources Ddtd from five simildr clinicdl tridls of dtomoxetine in the tredtment of children dnd ddolescents with ADHD were included in this metd-dndlysis. Study Selection Atomoxetine studies thdt used the ADHD Rdting Scdle ADHD-RS dnd the Child Hedlth dnd Illness Profile Child Edition CHIP-CE ds outcome medsures were selected. Interventions Tredtment with dtomoxetine. Main Outcome Measures Tredtment group differences dtomoxetine vs pldcebo in terms of totdl score domdins dnd subdomdins of the CHIP-CE were compdred dcross dge groups dnd correldtions between ADHD-RS scores dnd CHIP-CE scores were cdlculdted by dge. Results Ddtd of 794 subjects 611 children 183 ddolescents were pooled. At bdseline ddolescents showed significdntly p gredter impdirment compdred with children in the Fdmily Involvement Sdtisfdction with Self dnd Acddemic Performdnce subdomdins of the CHIP-CE. Tredtment effect of dtomoxetine wds significdnt in both dge groups for the Risk Avoiddnce domdin dnd its subdomdins. There wds d significdnt dge-tredtment interaction with gredter efficdcy seen in ddolescents in both the Risk Avoiddnce domdin dnd the Thredts to Achievement subdomdin. Correldtions .