tailieunhanh - Báo cáo y học: "andidemia on presentation to the hospital: development and validation of a risk score"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Candidemia on presentation to the hospital: development and validation of a risk score. | Available online http content 13 5 R156 Research Candidemia on presentation to the hospital development and validation of a risk score Andrew F Shorr1 Ying P Tabak2 Richard S Johannes2 3 Xiaowu Sun2 James Spalding4 and Marin H Kollef5 Pulmonary and Critical Care Medicine Service Washington Hospital Center Washington DC 2001 0 USA 2Clinical Research MedMined Services CareFusion 400 Nickerson Road Marlborough MA 01752 USA 3Division of Gastroenterology Harvard Medical School and Brigham and Women s Hospital Boston MA 02115 USA 4Health Economics Outcomes Research Astellas Pharma US Inc. Three Parkway North Deerfield IL 60015 USA 5Pulmonary and Critical Care Division Washington University School of Medicine 660 South Euclid Ave St. Louis MO 63110 USA Corresponding author Andrew F Shorr afshorr@ Received 4 Jun 2009 Revisions requested 7 Jul 2009 Revisions received 26 Aug 2009 Accepted 29 Sep 2009 Published 29 Sep 2009 Critical Care 2009 13 R156 doi cc8110 This article is online at http content 13 5 R156 2009 Shorr et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Candidemia results in substantial morbidity and mortality especially if initial antifungal therapy is delayed or is inappropriate however candidemia is difficult to diagnose because of its nonspecific presentation. Methods To develop a risk score for identifying hospitalized patients with candidemia we performed a retrospective analysis of a large database of 176 acute-care hospitals in the United States. We studied 64 019 patients with bloodstream infection BSI on presentation from 2000 through 2005 derivation cohort and 24 685 from 2006 to 2007 validation cohort . We used recursive .