tailieunhanh - Báo cáo y học: "Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study. | Available online http content 13 5 R155 Research Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry an observational study Joshua S Davis1 2 Tsin W Yeo1 Jane H Thomas3 Mark McMillan1 Christabelle J Darcy1 Yvette R McNeil1 Allen C Cheng1 2 David S Celermajer4 Dianne P Stephens3 and Nicholas M Anstey1 2 International Health Division Menzies School of Health Research and Charles Darwin University Rocklands Drive Darwin NT 0810 Australia 2Division of Medicine Royal Darwin Hospital Rocklands Drive Darwin NT 0810 Australia intensive Care Unit Royal Darwin Hospital Rocklands Drive Darwin NT 0810 Australia 4Department of Medicine University of Sydney and Department of Cardiology Royal Prince Alfred Hospital Missenden Road Sydney NSW 2006 Australia Corresponding author Nicholas M Anstey Received 20 Apr 2009 Revisions requested 30 Jun 2009 Revisions received 6 Aug 2009 Accepted 25 Sep 2009 Published 25 Sep 2009 Critical Care 2009 13 R155 doi cc8055 This article is online at http content 13 5 R155 2009 Davis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sepsis has a high mortality despite advances in management. Mieroeireulatory and endothelial dysfunction contribute to organ failure and better tools are needed to assess microcirculatory responses to adjunctive therapies. We hypothesised that peripheral arterial tonometry PAT a novel user-independent measure of endothelium-dependent microvascular reactivity would be impaired in proportion to sepsis severity and related to endothelial activation and plasma arginine concentrations. Methods Observational cohort study in a 350-bed teaching hospital .