tailieunhanh - Báo cáo y học: "A new integrative weaning index of discontinuation from mechanical ventilation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A new integrative weaning index of discontinuation from mechanical ventilation. | Available online http content 13 5 R152 Research A new integrative weaning index of discontinuation from mechanical ventilation Sergio N Nemer1 Carmen SV Barbas2 Jefferson B Caldeira1 Thiago C Cárias1 Ricardo G Santos1 Luiz C Almeida1 Leandro M Azeredo1 Rosângela A Noé3 Bruno S Guimarães1 and Paulo C Souza1 Open Access Critical Care Department Hospital de Clínicas de Niterói Rua La Salle 12 Centro Niterói Rio de Janeiro CEP 24020-090 Brazil 2Pulmonary and Critical Care Department Hospital das Clínicas de São Paulo Avenida Dr. Enéas de Carvalho Aguiar sétimo andar sala 7079 São Paulo CEP 05403-000 Brazil 3Biostatistics Department Universidade Federal do Rio de Janeiro Gávea Rio de Janeiro 22631-180 Brazil Corresponding author Sergio N Nemer snnemer@ Received 24 Mar 2009 Revisions requested 15 May 2009 Revisions received 8 Aug 2009 Accepted 22 Sep 2009 Published 22 Sep 2009 Critical Care 2009 13 R152 doi cc8051 This article is online at http content 13 5 R152 2009 Nemer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Indexes predicting weaning outcome are frequently inaccurate. We developed a new integrative weaning index aimed at improving the accuracy of the traditional indexes. Methods Three hundred and thirty-one patients mechanically-ventilated for more than 24 hours were evaluated. Initially the threshold values of each index that best discriminate between a successful and an unsuccessful weaning outcome were determined in 115 patients. In the second phase the predictive performance of these values was tested prospectively in the other 216 patients. Frequency tidal volume ratio f Vt ratio tidal volume Vt tracheal airway occlusion pressure s P .