tailieunhanh - Báo cáo y học: " Cardiac effects of induction agents in the septic rat heart"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cardiac effects of induction agents in the septic rat heart. | Available online http content 13 5 R144 Research Cardiac effects of induction agents in the septic rat heart York A Zausig Hendrik Busse Dirk Lunz Barbara Sinner Wolfgang Zink and Bernhard M Graf Department of Anaesthesiology and Critical Care University of Regensburg Franz-Josef-Strauss-Allee 11 Regensburg 93053 Germany Corresponding author York A Zausig Received 3 Aug 2009 Revisions requested 28 Aug 2009 Revisions received 2 Sep 2009 Accepted 8 Sep 2009 Published 8 Sep 2009 Critical Care 2009 13 R144 doi cc8038 This article is online at http content 13 5 R1 44 2009 Zausig et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The current debate about the side effects of induction agents . possible adrenal suppression through etomidate emphasizes the relevance of choosing the correct induction agent in septic patients. However cardiovascular depression is still the most prominent adverse effect of these agents and might be especially hazardous in septic patients presenting with a biventricular cardiac dysfunction - or so-called septic cardiomyopathy. Therefore we tested the dose-response direct cardiac effects of clinically available induction agents in an isolated septic rat heart model. Methods A polymicrobial sepsis was induced via cecal ligation and single puncture. Hearts n 50 were isolated and randomly assigned to five groups each receiving etomidate s -ketamine midazolam propofol or methohexitone at concentrations of 1 X 10 8 to 1 X 10 4 M. Left ventricular pressure contractility and lusitropy and coronary flow were measured. Cardiac work myocardial oxygen delivery oxygen consumption and percentage of oxygen .