tailieunhanh - Báo cáo y học: "Role of chlorhexidine gluconate in ventilator-associated pneumonia prevention strategies in ICU patients: where are we headed"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Role of chlorhexidine gluconate in ventilator-associated pneumonia prevention strategies in ICU patients: where are we headed? | Available online http content 13 6 427 Letter Role of chlorhexidine gluconate in ventilator-associated pneumonia prevention strategies in ICU patients where are we headed Tanmay S Panchabhai1 and Neha S Dangayach2 1 Department of Medicine University of Louisville School of Medicine ACB 3rd Floor 550 S. Jackson Street Louisville KY 40202 USA 2Department of Neurology Case Western Reserve University School of Medicine 11100 Euclid Avenue Cleveland OH 44106 USA Corresponding author Tanmay S Panchabhai tspanchabhai@ Published 27 November 2009 This article is online at http content 13 6 427 2009 BioMed Central Ltd Critical Care 2009 13 427 doi cc8165 See related research by Scannapieco et al. http content 13 4 R117 We read with interest the recent study by Seannapieeo and colleagues 1 which concluded that twice-daily oral rinse with chlorhexidine failed to reduce the number of potential respiratory pathogens in dental plaque mortality the incidence of ventilator-associated pneumonia VAP the length of intensive care unit ICU stay and the duration of mechanical ventilation in trauma ICU patients. Trauma ICU patients are similar to mixed ICU patients with respect to risk factors for developing VAP unlike patients undergoing elective cardiac surgery. Use of chlor-hexidine decreases the incidence of VAP in patients undergoing elective cardiac surgery. In mixed ICU patients chlor-hexidine at concentrations less than has consistently been shown to have no benefit 2 . A randomized trial using 2 chlorhexidine has however demonstrated a reduction in VAP rates in these patients 3 . A previous study showed that 12-hourly application of chlorhexidine has a sustained preventive effect on biofilm formation 4 . The lack of benefit from twice-daily oral cleansing with chlorhexidine in the present study may be due to the lower concentration of chlorhexidine. The authors recommendation for investigation into mechanical .