tailieunhanh - Báo cáo y học: "Death to sepsis: targeting apoptosis pathways in sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Death to sepsis: targeting apoptosis pathways in sepsis. | Available online http content 13 6 1010 Commentary Death to sepsis targeting apoptosis pathways in sepsis Derek S Wheeler1 2 3 1 Pediatric Intensive Care Unit Division of Critical Care Medicine Cincinnati Children s Hospital Medical Center 3333 Burnet Avenue Cincinnati OH 45229-3039 USA 2The Kindervelt Laboratory for Critical Care Medicine Research Cincinnati Children s Research Foundation 3333 Burnet Avenue Cincinnati OH 45229-3039 USA 3Department of Pediatrics University of Cincinnati College of Medicine 3333 Burnet Avenue Cincinnati OH 45229-3039 USA Corresponding author Derek S Wheeler Published 7 December 2009 This article is online at http content 13 6 1010 2009 BioMed Central Ltd Critical Care 2009 13 1010 doi cc8162 See related research by Weber et al. http content 13 5 R146 Abstract Sepsis is a significant public health problem and is one of the leading causes of death in critically ill patients admitted to the intensive care unit. The cost both in terms of lives lost and annual healthcare expenditures from sepsis is staggering. Unfortunately despite an increasing understanding of the unique molecular pathobiology of sepsis mortality has remained more or less stable over the past decade. Moreover promising therapies in preclinical models of sepsis have universally failed to live up to initial expectations in subsequent clinical trials. Multiple studies have demonstrated that apoptosis plays a major role in the pathobiology of sepsis and acute lung injury making the apoptosis pathway an attractive target for therapy. Herein the role of apoptosis in sepsis is briefly discussed highlighting studies with one potential therapeutic agent targeting the apoptosis pathway. Weber and colleagues recently demonstrated that the broad caspase inhibitor VX-166 significantly inhibited lymphocyte apoptosis and improved survival in two complementary rodent models of sepsis - endotoxin shock and cecal .