tailieunhanh - Báo cáo y học: "Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsi"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis? | Available online http content 13 6 1006 Commentary Matrix metalloproteinases and their inhibitors promising novel biomarkers in severe sepsis Ursula Hoffmann Martina Brueckmann and Martin Borggrefe 1st Department of Medicine Faculty of Medicine Mannheim University of Heidelberg Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim Germany Corresponding author Ursula Hoffmann Published 1 December 2009 This article is online at http content 13 6 1006 2009 BioMed Central Ltd Critical Care 2009 13 1006 doi cc8156 See related research by Lorente et al. http content 13 5 R158 Abstract The multicenter study conducted by Lorente and coworkers published in the previous issue of Critical Care demonstrates that matrix metalloproteinase MMP -9 and MMP-10 and their inhibitor tissue inhibitor of matrix metalloproteinase-1 TIMP-1 are promising novel biomarkers to predict severity and outcome of sepsis. In recent years MMPs have emerged as biomarkers in a variety of diseases such as sepsis coronary artery disease cancer heart failure chronic lung disease and rheumatoid arthritis. MMPs constitute a family of proteinases that are expressed during developmental physiological and pathophysiological processes for example as a response to infection. Excessive inflammation following infection may cause tissue damage and MMPs are implicated in causing this immunopathology. The activity of MMPs is regulated by secretion of specific inhibitors TIMPs . Studies using MMP inhibitors and MMP knockout mice indicate that MMPs play an essential role in infection and in the host response to infection. The measurement of MMP-9 and MMP-10 and their inhibitor TIMP-1 in the intensive care setting could be an attractive noninvasive tool for determination of outcome of septic patients. Introduction In the previous issue of Critical Care Lorente and coworkers reported the results of a prospective cohort study evaluating matrix metalloproteinases MMPs .