tailieunhanh - Báo cáo y học: "Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study. | Available online http content 13 4 R130 Research Continuous terlipressin versus vasopressin infusion in septic shock TERLIVAP a randomized controlled pilot study Andrea Morelli1 Christian Ertmer2 Sebastian Rehberg2 Matthias Lange2 Alessandra Orecchioni1 Valeria Cecchini1 Alessandra Bachetoni3 Mariadomenica D Alessandro3 Hugo Van Aken2 Paolo Pietropaoli1 and Martin Westphal2 1 Department of Anesthesiology and Intensive Care University of Rome La Sapienza Viale del Policlinico 155 Rome 00161 Italy laboratory of Clinical Pathology Department of Surgery University of Rome La Sapienza Viale del Policlinico 155 Rome 00161 Italy department of Anesthesiology and Intensive Care University Hospital of Muenster Albert-Schweitzer-Strasse 33 Muenster 48149 Germany Corresponding author Andrea Morelli .it Received 3 Jun 2009 Revisions requested 30 Jun 2009 Revisions received 13 Jul 2009 Accepted 10 Aug 2009 Published 10 Aug 2009 Critical Care 2009 13 R130 doi cc7990 This article is online at http content 13 4 R130 2009 Morelli et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Recent clinical data suggest that early administration of vasopressin analogues may be advantageous compared to a last resort therapy. However it is still unknown whether vasopressin and terlipressin are equally effective for hemodynamic support in septic shock. The aim of the present prospective randomized controlled pilot trial study was therefore to compare the impact of continuous infusions of either vasopressin or terlipressin when given as first-line therapy in septic shock patients on open-label norepinephrine requirements. Methods We enrolled septic shock patients n