tailieunhanh - Báo cáo y học: " Epinephrine kinetics in septic shock - a means to understand variable catecholamine efficiency"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Epinephrine kinetics in septic shock - a means to understand variable catecholamine efficiency? | Available online http content 13 4 177 Commentary Epinephrine kinetics in septic shock - a means to understand variable catecholamine efficiency Enrico Calzia1 Michael Georgieff1 Markus Huber-Lang2 and Peter Radermacher1 1Sektion Anasthesiologische Pathopyhsiologie und Verfahrensentwicklung Klinik fur Anasthesiologie Parkstrasse 11 89073 Ulm Germany 2Klinik fur Unfall- Hand- Plastische- und Wiederherstellungschirurgie Universitatsklinikum Steinhovelstrasse 9 89075 Ulm Germany Corresponding author Peter Radermacher Published 13 August 2009 This article is online at http content 13 4 177 2009 BioMed Central Ltd Critical Care 2009 13 177 doi cc7987 See related research by Abboud et al. http content 13 4 R120 Abstract It is well-established that the hemodynamic response to infusing catecholamines the most frequently applied drugs for circulatory support during shock states may vary markedly within and between individuals. In this context it is striking that only scarce data are available on the pharmacokinetics of catecholamines in critically ill patients. Furthermore the existing literature comprises fairly equivocal observations. Abboud and colleagues now report that in patients with septic shock epinephrine kinetics are linear and its clearance directly depends on body weight and is inversely related to the severity of the disease. The authors conclude that the endogenous adrenal axis hormones do not assume any additional importance. Catecholamines still represent the drugs of choice for hemodynamic support during circulatory shock. It is well known that the responsiveness to catecholamines shows pronounced inter- and even intra-individual variability. This variable efficiency might theoretically result from differences in catecholamine pharmacokinetics but the available literature on this subject is surprisingly rare. In this issue of Critical Care Abboud and colleagues describe the .