tailieunhanh - Báo cáo y học: "Bone mineral density in partially recovered early onset anorexic patients - a follow-up investigation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bone mineral density in partially recovered early onset anorexic patients - a follow-up investigation. | Schulze et al. Child and Adolescent Psychiatry and Mental Health 2010 4 20 http content 4 1 20 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH RESEARCH Open Access Bone mineral density in partially recovered early onset anorexic patients - a follow-up investigation 1 2 4 3 1 Ulrike ME Schulze Simone Schuler Dieter Schlamp Peter Schneider Claudia Mehler-Wex Abstract Background and aims There still is a lack of prospective studies on bone mineral development in patients with a history of early onset Anorexia nervosa AN . Therefore we assessed associations between bone mass accrual and clinical outcomes in a former clinical sample. In addition to an expected influence of regular physical activity and hormone replacement therapy we explored correlations with nutritionally dependent hormones. Methods 3-9 years mean after hospital discharge we re-investigated 52 female subjects with a history of early onset AN. By means of a standardized approach we evaluated the general outcome of AN. Moreover bone mineral content BMC and bone mineral density BMD as well as lean and fat mass were measured by dualenergy x-ray absorptiometry DXA . In a substudy we measured the serum concentrations of leptin and insulin-like growth factor-I IGF-I . Results The general outcome of anorexia nervosa was good in 50 of the subjects BMI kg m2 resumption of menses . Clinical improvement was correlated with BMC and BMD accrual c2 2 p p . The duration of amenorrhea had a negative correlation with BMD r p but not with BMC. Regular physical activity tended to show a positive effect on bone recovery but the effect of hormone replacement therapy was not significant. Using age-related standards the post-discharge sample for the substudy presented IGF-I levels below the 5th percentile. IGF-I serum concentrations corresponded to the general outcome of AN. By contrast leptin serum concentrations showed great variability. They correlated with BMC and .